International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 8 Issue 5
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Bioactive Profiling of Moringa oleifera (Shigru): A Critical Review on the Antimicrobial Synergy of Stem Bark and Seed Extracts

Author(s) Dr. Nishesh Parteek, Dr. Rohit Johari
Country India
Abstract Moringa oleifera Lam. (Shigru) is a widely used medicinal plant in Ayurvedic and folk-health traditions and is increasingly investigated for antimicrobial activity. This critical review examines the bioactive profile of stem bark and seed extracts with special emphasis on possible synergistic antimicrobial interactions. Stem bark is comparatively rich in tannins, phenolics, alkaloids and sterol-like constituents, whereas seeds contain glucosinolate-derived isothiocyanates, lectins, flavonoids and fixed oils. These molecules may act through complementary pathways such as microbial membrane damage, protein precipitation, oxidative stress, enzyme inhibition, interference with energy metabolism and suppression of DNA/protein synthesis. Available in-vitro evidence suggests that Moringa extracts inhibit Gram-positive bacteria, Gram-negative bacteria and selected fungi; recent reports also indicate extract-antibiotic synergy, especially with beta-lactam antibiotics against resistant organisms. From an Ayurvedic perspective, the Katu-Tikta Rasa, Ushna Virya, Tikshna Guna and Krimighna karma of Shigru provide a rational traditional framework for use in infection-associated conditions. However, direct stem bark-seed synergy remains underexplored and requires standardized extraction, phytochemical fingerprinting, checkerboard/FIC studies, toxicity testing and translational formulation research. This review concludes that stem bark and seed extracts are promising complementary antimicrobial resources, but robust experimental and clinical validation is essential before therapeutic claims are made. [1-8]
Keywords Moringa oleifera; Shigru; antimicrobial synergy; stem bark; seed extract; Ayurveda; phytochemistry; antibiotic resistance
Published In Volume 8, Issue 5, September-October 2026
Published On 2026-10-08
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E-ISSN 2582-2160
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CrossRef DOI prefix of IJFMR is 10.36948/ijfmr

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