Multiparticulate Pellet Systems and Extended-Release Coating Strategies for Targeted Therapy in Ulcerative Colitis: A Review

Author(s)	Mrs Kadeeja Ruwaidah, Dr. Valli Manalan
Country	India
Abstract	Ulcerative colitis (UC) is a chronic, recurring inflammatory bowel disease confined to the colon and rectum's mucosal lining. A key formulation challenge is delivering therapeutic drug concentrations directly to the colonic mucosa while preventing premature release in the upper gastrointestinal tract. Multiparticulate pellet systems offer significant biopharmaceutical advantages over single-unit monolithic dosage forms, including consistent gastrointestinal transit, a lower risk of dose dumping, and predictable dispersion within the colon. This review explores the physiological changes in the UC gastrointestinal tract, production techniques for functional multiparticulates (like extrusion-spheronization and fluid-bed coating), and targeted extended-release coating mechanisms. It emphasizes pH-dependent, time-dependent, microbial enzyme-triggered, and hybrid dual-mechanism coating platforms. Preclinical and clinical performance, regulatory considerations, and emerging nano-in-micro multiparticulate platforms are highlighted to outline future clinical applications.
Field	Medical / Pharmacy
Published In	Volume 8, Issue 5, September-October 2026
Published On	2026-10-10

About IJFMR Fees & Payment Current Issue Publication Archive	Submit Research Paper Track Submission Status Publication Guidelines Publication Ethics Peer Review & Plagiarism	Join as a Reviewer Editors & Reviewers Reviewer Referral Program Get Reviewer Membership Certi.	Website/Journal Policies Usage Policy Content Policies Privacy Policy

Contact Us		+91-9687-828-838	editor@ijfmr.com

International Journal For Multidisciplinary Research