International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 8 Issue 5
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Reviewing Local Hospital Antibiograms and Community-Acquired Infection Patterns to Map Out Changing Resistance Profiles for Common Pathogens

Author(s) Dr. Mohammed Khaja Moinudeen, Dr. Lok Ranjan R, Ms. Pathan Maseeha Tabassum, Mr. Vikhyat Vaibhav, Ms. Dhiya Catherine
Country India
Abstract Antimicrobial resistance (AMR) represents an escalating global healthcare crisis, driven by evolving resistance patterns among bacterial pathogens in both community and healthcare settings. Local antibiograms are essential epidemiological instruments for tracking resistance trends, informing empiric therapy, and supporting antimicrobial stewardship programs (ASPs). A persistent challenge is the discrepancy between resistance patterns reported in inpatient antibiograms and the actual resistance profiles of pathogens causing community-acquired infections (CAIs). This divergence can lead to inappropriate empiric therapy and unnecessary use of broad-spectrum antibiotics. This review examines the methodology of compiling and interpreting local antibiograms in accordance with CLSI M39 guidelines, emphasizing duplicate-isolate exclusion, minimum isolate thresholds, standardized susceptibility data analysis, and inpatient–outpatient stratification. It further analyzes resistance trends among key pathogens, including Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Streptococcus pneumoniae, while exploring clinical strategies to address surveillance gaps and improve the reliability of resistance estimates and the appropriateness of empirical antimicrobial therapy. The integration of longitudinal susceptibility data with regional resistance phenotypes facilitates the development of more effective empiric guidelines, reduces selective pressure, and enhances patient outcomes.
Field Medical / Pharmacy
Published In Volume 8, Issue 5, September-October 2026
Published On 2026-10-16
DOI https://doi.org/10.36948/ijfmr.2026.v08i05.89962
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CrossRef DOI prefix of IJFMR is 10.36948/ijfmr

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