International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 8 Issue 5
September-October 2026

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Urinary Iodine Concentration Across Thyroid Functional States: A Comparative Biochemical Study in Adults

Author(s) Mr. Santosh Kuchela, Dr. Avinash Sharma
Country India
Abstract Abstract:
Background: Iodine availability contributes to thyroid hormone synthesis, but urinary iodine concentration (UIC), thyroid function and thyroid autoimmunity represent different biological processes. A single urine measurement reflects recent exposure and dilution and cannot establish an individual’s habitual iodine status. Comparisons across thyroid functional states therefore require careful phenotyping, treatment documentation and transparent reporting of uncertainty.
Objective: To establish a reproducible approach for describing UIC distributions and comparing serum thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4) and anti-thyroid peroxidase (anti-TPO) antibodies among adults with different thyroid functional states.
Methods: An analytical cross-sectional study is proposed among consenting, nonpregnant adults recruited through an approved clinical setting. Current thyroid function will be classified as euthyroid, hypothyroid or hyperthyroid using laboratory-specific reference intervals and clinical review. Autoimmune status and treatment history will be recorded separately. Spot urine and serum specimens will be collected under a standard operating procedure. UIC will be analysed using a validated assay with internal quality control. Primary reporting will include group-specific medians, interquartile ranges, valid denominators and confidence intervals for prespecified contrasts. Adjusted analyses will account for selected demographic, exposure and clinical covariates when the available sample supports them.
Results status: Recruitment, assay results and participant-level data were not supplied for this manuscript. Consequently, no original numerical results, significance tests or observed group differences are reported. The paper specifies the analysis and reporting framework to be completed after approved data collection.
Conclusion: Comparing UIC with clinically characterised thyroid profiles may clarify biochemical heterogeneity within the recruited sample. Its contribution will depend on avoiding individual diagnostic claims from single spot UIC measurements, separating thyroid function from autoimmune aetiology, and distinguishing contemporaneous associations from causation.
Keywords Keywords: urinary iodine concentration; thyroid function; thyroid-stimulating hormone; free thyroxine; thyroid autoimmunity; adults; cross-sectional study
Field Medical / Pharmacy
Published In Volume 8, Issue 5, September-October 2026
Published On 2026-10-22
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E-ISSN 2582-2160
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CrossRef DOI prefix of IJFMR is 10.36948/ijfmr

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