International Journal For Multidisciplinary Research

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Formulation and Evaluation of Liposomes containing Metformin Hydrochloride

Author(s) SUSHMA WADBUDHE, SANJANA MAHAJAN, MAYUR KHAN, SAHIL KSHIRSAGAR
Country India
Abstract The characterization and evaluation of metformin hydrochloride-loaded liposomal formulations are critical processes aimed at assessing their effectiveness and suitability for medical use. These formulations, composed of small synthetic vesicles called liposomes, are designed to enhance the delivery and efficacy of metformin, a widely used medication for managing type 2diabetes. Liposomes, with their unique blend of hydrophobic and hydrophilic properties, offer promising advantages in drug delivery. One key aspect of this process involves characterizing the liposomal formulations. This characterization entails examining various parameters such as size, surface charge, morphology, and encapsulation efficiency. Techniques like dynamic light scattering, zeta potential analysis, and microscopy are employed for this purpose, providing valuable insights into the physical properties of the liposomes. Additionally, the stability of the liposomal formulations is thoroughly assessed. This involves evaluating their physical and chemical stability under various storage conditions, including temperature and humidity variations, over a defined period. Ensuring the stability of the formulations is essential for maintaining their efficacy during storage and transportation. Finally, if feasible, preclinical pharmacokinetic studies are conducted in appropriate animal models to evaluate the bio distribution, systemic exposure, and pharmacokinetic parameters of metformin hydrochloride following administration of the liposomal formulations. These studies help determine the drug's behavior in living organisms and its potential therapeutic benefits
Keywords Drug loaded Liposomes, Liposomal formulation
Field Medical / Pharmacy
Published In Volume 6, Issue 2, March-April 2024
Published On 2024-03-28
Cite This Formulation and Evaluation of Liposomes containing Metformin Hydrochloride - SUSHMA WADBUDHE, SANJANA MAHAJAN, MAYUR KHAN, SAHIL KSHIRSAGAR - IJFMR Volume 6, Issue 2, March-April 2024. DOI 10.36948/ijfmr.2024.v06i02.15833
DOI https://doi.org/10.36948/ijfmr.2024.v06i02.15833
Short DOI https://doi.org/gtppdj
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