International Journal For Multidisciplinary Research

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Development and Validation of UV Spectroscopic method for the estimation of favipiravir in bulk and tablet dosage form

Author(s) Harshitha M, Sowmy H G, Naveen Kumar G S
Country India
Abstract Simple, precise and accurate area under curve spectroscopic method has been developed and validated for the estimation of Favipiravir in bulk and pharmaceutical dosage form. The drug shows maximum absorption (λ max) at 361nm in 0.1N NaOH solution and Area under Curve [AUC] in absorption spectra were measured between the wavelength range 356 to 366nm which obeys Beer’s law in the concentration range of 2-10µg/ml. The linearity study carried and regression coefficient was found to be 0.9982 and it has showed good linearity, precision during this concentration range. The % recovery was found to be 98.6-101.1. The LOD and LOQ were found to be 0.055 and 0.168µg/ml. The % relative standard deviation were found less than 2. According to ICH guidelines the method has been validated for linearity, precision, accuracy, robustness, ruggedness, LOD and LOQ. The developed and validated method can be successfully applied for reliable quantification of Favipiravir in bulk form and pharmaceutical dosage form.
Keywords Favipiravir, Area under curve spectroscopy, validation, pharmaceutical formulations.
Field Medical / Pharmacy
Published In Volume 6, Issue 2, March-April 2024
Published On 2024-04-13
Cite This Development and Validation of UV Spectroscopic method for the estimation of favipiravir in bulk and tablet dosage form - Harshitha M, Sowmy H G, Naveen Kumar G S - IJFMR Volume 6, Issue 2, March-April 2024. DOI 10.36948/ijfmr.2024.v06i02.17030
DOI https://doi.org/10.36948/ijfmr.2024.v06i02.17030
Short DOI https://doi.org/gtqxst
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