International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Evaluating the Bioactive Potential of Cinnamomum verum against Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus

Author(s) Ms. Aafiya Taiyab Noorani, Payal Jadhav, Chinmayee Mahadik
Country India
Abstract Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus are the most common causes of skin infections globally. Due to the increase in antibiotic-resistant strains and the numerous side effects caused by conventional synthetic drugs, new antimicrobials must be developed. One such promising source is Cinnamomum verum, which is cultivated mainly in the southern regions and northeastern states of India. This research utilises the potential antibacterial activity of cinnamon, particularly its active component, cinnamaldehyde, which can suppress the production of toxins by disrupting the integrity of bacterial cell membranes. Cinnamon crude extract was prepared from the cinnamon bark using organic solvent extraction. Phytochemical tests of the cinnamon extract revealed the presence of active secondary metabolites, namely alkaloids, saponins, resins and terpenoids. A comparative analysis evaluated the antibacterial efficacy of cinnamaldehyde and ampicillin against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). The results demonstrated that cinnamaldehyde exhibited antibacterial activity comparable to ampicillin, highlighting its potential as an effective alternative for combating these pathogens. The minimum inhibitory concentration (MIC) study of the extract was also determined for further applications. Crude extract was incorporated into different formulations with oil, petroleum jelly, starch and carboxymethyl cellulose, among which starch and petroleum jelly gave positive results. In the future, cinnamaldehyde-infused hydrogel-based topicals could serve as a safer and more accessible alternative for managing Staphylococcus aureus infections, particularly in regions where these infections pose significant public health challenges.
Keywords Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, antibiotic-resistant, Cinnamomum verum, formulations, oil, petroleum jelly, starch and carboxymethyl cellulose
Field Medical / Pharmacy
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-12-28
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.64352
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E-ISSN 2582-2160
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