International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 8 Issue 2
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Meta-Analytic Guided Design of Green Synthesized Cu-Zn Nanoparticles from Malunggay (Moringa oleifera) Leaves' Extract and its Exploratory Antibacterial Activity against Klebsiella pneumoniae

Author(s) Ms. Jen Vania Jumamil Jabagat, Ms. Elaiza Marie Cabodbod Encienzo, Ms. Ayessa Pascual Dapitan
Country Philippines
Abstract The rapid emergence of multidrug-resistant (MDR) pathogens, particularly Klebsiella pneumoniae, poses a critical global health threat and necessitates alternative antimicrobial strategies. This study explores the green synthesis of bimetallic copper-zinc (Cu-Zn) nanoparticles using aqueous leaf extract of Malunggay (Moringa oleifera) as a natural reducing and stabilizing agent, guided by a meta-analytic review of related literature. Existing studies on copper, zinc, and plant-mediated nanoparticles were systematically examined to identify synthesis parameters and antimicrobial trends relevant to MDR microorganisms. Based on the synthesized evidence, Cu-Zn nanoparticles were produced through an eco-friendly method and characterized in terms of size, shape, and structural properties. The antibacterial activity of the synthesized nanoparticles was then evaluated against Klebsiella pneumoniae at varying metal ratios (1:1, 1:3, and 3:1). Findings from the meta-analysis indicated an overall positive antimicrobial effect of green-synthesized metal nanoparticles despite heterogeneity across studies. Experimental results demonstrated that malunggay-mediated Cu-Zn nanoparticles exhibit inhibitory activity against Klebsiella pneumoniae, suggesting synergistic effects between copper and zinc components. This study highlights the potential of plant-based bimetallic nanoparticles as sustainable and cost-effective alternatives to conventional antibiotics. By integrating meta-analysis with laboratory synthesis, the research contributes to the growing field of green nanotechnology and supports the development of novel antimicrobial agents to combat drug-resistant bacterial infections.
Keywords Moringa oleifera (Malunggay), green synthesis, copper nanoparticles (CuNPs), zinc nanoparticles (ZnNPs), copper–zinc bimetallic nanoparticles (Cu–Zn NPs), Klebsiella pneumoniae
Field Biology > Medical / Physiology
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-03-03
DOI https://doi.org/10.36948/ijfmr.2026.v08i02.70259
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